Big Pharma Is Buying — Why Biotech Could Outperform in 2026

February 23, 2026

Mish's Daily

By Mish Schneider

Biotech is quietly stepping into a leadership role here in early 2026 — and the move is not happening in a vacuum.

After years of underperformance from 2021 through much of 2024, the sector began a powerful rebound in the second half of 2025.

That rally was significant. From its April 2025 lows, the SPDR S&P Biotech ETF surged roughly 75%, dramatically outperforming the broader market’s move over the same period.

In many ways, that outperformance looked like a long-overdue catch-up trade.

The real question now is whether that catch-up has further to run — or whether biotech is shifting into a sustained leadership phase.

Right now, the evidence suggests the latter.

The Fundamental Tailwinds

Healthcare demand continues to grow globally, and with it, investment into biotechnology. This is not just speculative capital — it is strategic capital flowing into innovation pipelines.

Advancements in gene editing and next-generation therapies are accelerating research timelines and expanding what is medically possible. At the same time, we are seeing a steady stream of encouraging clinical trial data and improved FDA filing activity.

Successful trials and new approvals create real valuation support for companies across the biotech space. These are not hypothetical technologies anymore — they are moving toward commercialization and revenue generation.

Another key factor is public awareness. Acceptance of biotechnology solutions, from genetic therapies to obesity drugs to personalized medicine, continues to expand. That growing comfort level helps support demand, funding, and long-term adoption.

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Follow the Big Money: M&A and Partnerships

Perhaps the most important theme to watch in 2026 is mergers and acquisitions.

Large pharmaceutical companies are facing major patent expirations — what the industry calls “loss of exclusivity” cliffs. Those cliffs represent massive revenue gaps that must be filled. The fastest way to fill them is by acquiring or partnering with innovative biotech firms that already have promising drug pipelines.

That dynamic sets up a supportive backdrop for biotech valuations.
Strategic partnerships and early-stage acquisitions can reward investors and create a floor under many emerging companies.

Capital Rotation Back to Risk

We are also seeing a rotation of capital back into higher-beta growth sectors, including biotech. After a period where investors favored mega-cap technology and defensive positioning, money is starting to move into areas with stronger upside potential.

Biotech sits squarely in that category.

When risk appetite improves, biotech often becomes a destination for capital seeking outsized returns. That rotation is one of the clearest signs of improving confidence in the broader market environment.

Risks to Respect

Of course, biotech is never without risk.

Interest rate pressures remain a macro consideration. Higher rates can weigh on growth-oriented sectors that rely heavily on future earnings potential. Regulatory headlines, drug pricing debates, and company-specific clinical setbacks can also introduce volatility.

There is also ongoing competition for capital. Artificial intelligence and other high-growth themes continue to attract significant investment flows that might otherwise find their way into biotech.

Yet despite these risks, sector fundamentals remain strong. Robust drug development pipelines, improving clinical data, and the likelihood of continued M&A activity all support the longer-term outlook.

The Bottom Line

Biotech’s recent outperformance is not just a short-term bounce. It reflects improving fundamentals, renewed capital flows, and strategic demand from large pharmaceutical companies.

If the sector continues to attract investment and deliver positive clinical and regulatory developments, leadership could persist well into 2026.

For investors and traders alike, biotech is no longer a space to ignore.
It is a space to watch closely — because when innovation, capital, and momentum align, this sector can move fast.
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